Chemotherapy drug cisplatin is used to treat breast, prostate, neuroblastoma, melanoma and many other cancers
May 18, 2016
University of Southern California
The chemotherapy drug cisplatin can kill cancer, but it can also cause permanent hearing loss. The drug can kill the sensory cells of the inner ear, a phenomenon that is likely more severe in individuals with Cockayne syndrome, a rare form of dwarfism. The disorder results from mutations in one of two genes involved in repairing DNA damage. Cells can sustain DNA damage from environmental stresses ranging from the sun's ultraviolet radiation to toxic chemicals such as chemotherapy drugs.
By HEARING LOSS HELP e-Zine "The premier e-Zine for people with hearing loss"
The Ototoxicity of Drugs Ending in“-mycin” (and “–micin”)
by Neil Bauman, Ph.D.
A number of people believe that drugs ending in “–mycin” (and
“-micin”) are all members of the extremely ototoxic Aminoglycoside
class of antibiotic drugs and should be avoided so they don’t damage
their ears. This is not totally true.
It is true that about half of the generic drugs ending in “–mycin” and
“–micin” are indeed members of the Aminoglycoside class of drugs.
However, it is just as true that about half of the drugs ending in
“–mycin” and “–micin” are not Aminoglycosides. Furthermore, some
Aminoglycoside drugs do not end in “–mycin” or “–micin”.
Complicating things further, not only do a number of generic drug
names end in –mycin and –micin, but so do a number of brand
names—again about half of which are Aminoglycoside drugs, and half are
Therefore, when you come across a drug name ending in “–mycin” or
“–micin” don’t automatically assume it is an Aminoglycoside drug.
(You’d be wrong about 50% of the time if you do.)
Below is a list of all the drugs (generic and brand names) that end in
“–mycin” or “–micin” of which I’m aware. All of them are ototoxic to
some degree—ranging from mildly ototoxic to extremely ototoxic.
Generic names ending in “-mycin/-micin” are in bold. Brand names are
in bold italics and drug class names are in UPPER CASE.
If you want to learn more about the ototoxic side effects of the
-mycins (or any other drugs), see the details of my book "Ototoxic
Drugs Exposed" 3rd edition or order one for yourself at http://hearinglosshelp.com/shop/ototoxic-drugs-exposed/ . This book
contains information on the ototoxicity of 877 drugs, 35 herbs and 148
Yet, one newly recognized risk usually goes unmentioned: hearing loss. “There are a number of common medications that are ototoxic, which means harmful to the ears,” says Dr. Sharon Curhan, a physician and epidemiologist at the Channing Division of Network Medicine at Brigham and Women’s Hospital and Harvard Medical School in Boston. That side effect isn't typically listed on drug labels, she says. "These are relatively new findings.”
Research by Curhan and others finds that some over-the-counter medications, acetaminophen (the generic name for Tylenol), ibuprofen and prescriptions, ranging from certain antibiotics to chemotherapy drugs, can damage hearing. In all, there are more than 200 known ototoxic medications on the market today, according to the American-Speech-Language-Hearing Association, which can also impact the ear's balance functions.
An experimental treatment could let children with a rare genetic disease live longer, but it may make them deaf
The Wall Street Journal,
AMY DOCKSER MARCUS
BETHESDA, Md.—While waiting for an infusion of a drug that might save his life, 15-year-old Andrew Marella gripped the controls of an NFL videogame, the hand-held version of a sport he played when he could still run without fear.
Andrew is in a clinical drug trial of cyclodextrin, a sugar-based substance that scientists hope will stop or slow the progress of a rare genetic disease that kills most patients by the time they are old enough to vote.
There is a good chance cyclodextrin will extend Andrew’s life. But his parents worry this will be the dose that leaves him deaf.
Families in the drug trial must decide whether to permit the higher doses of cyclodextrin that research shows might arrest the disease. Hearing loss is one side effect. “Deaf or death, what are our options?” said Andrea Marella, Andrew’s mother. “We have to keep moving forward.”